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It activates amylin receptor pathways and interacts with calcitonin receptor-related systems involved in satiety, appetite regulation, and metabolic signaling

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"Two concentrations of topical tretinoin (retinoic acid) cause similar improvement of photoaging but different degrees of irritation: a double-blind, vehicle-controlled comparison of 0.1% and 0.025% tretinoin creams." Archives of dermatology 131.9 (1995): 1037-1044

Effect of lycopene on oxidative ovarian damage induced by cisplatin in rats